HORDB

ID: hor004564
Uniprot ID: P0DM26
Protein name: Conorfamide-Tx1
Gene name: NA
Organism: Conus textile (Cloth-of-gold cone)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Expressed by the venom duct.
Disease: NA
Comments: NA
Taxonomy: Cylinder (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Function: This peptide does not show activity on human and mouse sensory neuron-specific G-protein coupled receptors MRGPRX1.
Mechanism: Negative results: the mature peptide does not contain cysteine residue.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004564_AF2.pdb

hor004564_ESM.pdb

Mass:	257653	Formula:	C99H153N25O34
Absent amino acids:	ACEHMQTW	Common amino acids:	D
pI:	4.02	Basic residues:	2
Polar residues:	6	Hydrophobic residues:	6
Hydrophobicity:	-46	Boman Index:	-4557
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	87.5
Instability Index:	2166	Extinction Coefficient cystines:	1490
Absorbance 280nm:	78.42